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SMILES: COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1cc(Cl)cc(Cl)c1

InChI Key:

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50577518   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50577518
PNG
(CHEMBL4855120)
Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1cc(Cl)cc(Cl)c1 |t:16|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 10n/an/an/an/a


TBA

Assay Description
Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00904
BindingDB Entry DOI: 10.7270/Q2RV0SJR
More data for this
Ligand-Target Pair