null

SMILES: CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccc(Cl)cc2)c(O)n1-c1c(OC)cccc1OC

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50577749   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM50577749 (CHEMBL4854048) Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccc(Cl)cc2)c(O)n1-c1c(OC)cccc1OC |(66.4,-48.76,;67.73,-49.53,;69.07,-48.76,;70.4,-49.53,;71.75,-48.76,;71.75,-47.22,;73.07,-46.46,;73.07,-44.9,;74.4,-47.22,;75.74,-46.44,;75.74,-44.9,;77.07,-47.21,;77.23,-48.74,;78.74,-49.06,;79.51,-47.72,;78.48,-46.58,;81.04,-47.56,;81.94,-48.81,;83.47,-48.66,;84.1,-47.25,;85.63,-47.09,;83.18,-46,;81.66,-46.16,;74.4,-48.74,;75.74,-49.51,;73.08,-49.51,;73.08,-51.04,;74.41,-51.81,;75.74,-51.03,;77.08,-51.8,;74.42,-53.36,;73.08,-54.13,;71.74,-53.36,;71.75,-51.82,;70.41,-51.05,;69.08,-51.82,)| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.150	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00385 BindingDB Entry DOI: 10.7270/Q2M330MF
					More data for this Ligand-Target Pair
Apelin receptor (Rattus norvegicus)	BDBM50577749 (CHEMBL4854048) Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccc(Cl)cc2)c(O)n1-c1c(OC)cccc1OC |(66.4,-48.76,;67.73,-49.53,;69.07,-48.76,;70.4,-49.53,;71.75,-48.76,;71.75,-47.22,;73.07,-46.46,;73.07,-44.9,;74.4,-47.22,;75.74,-46.44,;75.74,-44.9,;77.07,-47.21,;77.23,-48.74,;78.74,-49.06,;79.51,-47.72,;78.48,-46.58,;81.04,-47.56,;81.94,-48.81,;83.47,-48.66,;84.1,-47.25,;85.63,-47.09,;83.18,-46,;81.66,-46.16,;74.4,-48.74,;75.74,-49.51,;73.08,-49.51,;73.08,-51.04,;74.41,-51.81,;75.74,-51.03,;77.08,-51.8,;74.42,-53.36,;73.08,-54.13,;71.74,-53.36,;71.75,-51.82,;70.41,-51.05,;69.08,-51.82,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.170	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00385 BindingDB Entry DOI: 10.7270/Q2M330MF
					More data for this Ligand-Target Pair
Apelin receptor (Rattus norvegicus)	BDBM50577749 (CHEMBL4854048) Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccc(Cl)cc2)c(O)n1-c1c(OC)cccc1OC |(66.4,-48.76,;67.73,-49.53,;69.07,-48.76,;70.4,-49.53,;71.75,-48.76,;71.75,-47.22,;73.07,-46.46,;73.07,-44.9,;74.4,-47.22,;75.74,-46.44,;75.74,-44.9,;77.07,-47.21,;77.23,-48.74,;78.74,-49.06,;79.51,-47.72,;78.48,-46.58,;81.04,-47.56,;81.94,-48.81,;83.47,-48.66,;84.1,-47.25,;85.63,-47.09,;83.18,-46,;81.66,-46.16,;74.4,-48.74,;75.74,-49.51,;73.08,-49.51,;73.08,-51.04,;74.41,-51.81,;75.74,-51.03,;77.08,-51.8,;74.42,-53.36,;73.08,-54.13,;71.74,-53.36,;71.75,-51.82,;70.41,-51.05,;69.08,-51.82,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.170	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00385 BindingDB Entry DOI: 10.7270/Q2M330MF
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM50577749 (CHEMBL4854048) Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccc(Cl)cc2)c(O)n1-c1c(OC)cccc1OC |(66.4,-48.76,;67.73,-49.53,;69.07,-48.76,;70.4,-49.53,;71.75,-48.76,;71.75,-47.22,;73.07,-46.46,;73.07,-44.9,;74.4,-47.22,;75.74,-46.44,;75.74,-44.9,;77.07,-47.21,;77.23,-48.74,;78.74,-49.06,;79.51,-47.72,;78.48,-46.58,;81.04,-47.56,;81.94,-48.81,;83.47,-48.66,;84.1,-47.25,;85.63,-47.09,;83.18,-46,;81.66,-46.16,;74.4,-48.74,;75.74,-49.51,;73.08,-49.51,;73.08,-51.04,;74.41,-51.81,;75.74,-51.03,;77.08,-51.8,;74.42,-53.36,;73.08,-54.13,;71.74,-53.36,;71.75,-51.82,;70.41,-51.05,;69.08,-51.82,)| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.150	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00385 BindingDB Entry DOI: 10.7270/Q2M330MF
					More data for this Ligand-Target Pair