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SMILES: CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2cccnc2)c(O)n1-c1c(OC)cccc1OC

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50577751   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM50577751 (CHEMBL4863297) Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2cccnc2)c(O)n1-c1c(OC)cccc1OC |(64.87,-8.89,;66.21,-9.66,;67.54,-8.88,;68.88,-9.65,;70.23,-8.88,;70.22,-7.35,;71.55,-6.58,;71.55,-5.02,;72.87,-7.34,;74.21,-6.56,;74.21,-5.02,;75.54,-7.34,;75.7,-8.86,;77.21,-9.18,;77.98,-7.85,;76.95,-6.7,;79.51,-7.69,;80.41,-8.94,;81.94,-8.78,;82.57,-7.37,;81.66,-6.12,;80.13,-6.29,;72.88,-8.87,;74.21,-9.64,;71.55,-9.63,;71.55,-11.17,;72.89,-11.93,;74.22,-11.16,;75.55,-11.92,;72.89,-13.48,;71.55,-14.25,;70.22,-13.48,;70.22,-11.94,;68.89,-11.17,;67.55,-11.94,)| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.290	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00385 BindingDB Entry DOI: 10.7270/Q2M330MF
					More data for this Ligand-Target Pair
Apelin receptor (Rattus norvegicus)	BDBM50577751 (CHEMBL4863297) Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2cccnc2)c(O)n1-c1c(OC)cccc1OC |(64.87,-8.89,;66.21,-9.66,;67.54,-8.88,;68.88,-9.65,;70.23,-8.88,;70.22,-7.35,;71.55,-6.58,;71.55,-5.02,;72.87,-7.34,;74.21,-6.56,;74.21,-5.02,;75.54,-7.34,;75.7,-8.86,;77.21,-9.18,;77.98,-7.85,;76.95,-6.7,;79.51,-7.69,;80.41,-8.94,;81.94,-8.78,;82.57,-7.37,;81.66,-6.12,;80.13,-6.29,;72.88,-8.87,;74.21,-9.64,;71.55,-9.63,;71.55,-11.17,;72.89,-11.93,;74.22,-11.16,;75.55,-11.92,;72.89,-13.48,;71.55,-14.25,;70.22,-13.48,;70.22,-11.94,;68.89,-11.17,;67.55,-11.94,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.330	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00385 BindingDB Entry DOI: 10.7270/Q2M330MF
					More data for this Ligand-Target Pair
Apelin receptor (Rattus norvegicus)	BDBM50577751 (CHEMBL4863297) Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2cccnc2)c(O)n1-c1c(OC)cccc1OC |(64.87,-8.89,;66.21,-9.66,;67.54,-8.88,;68.88,-9.65,;70.23,-8.88,;70.22,-7.35,;71.55,-6.58,;71.55,-5.02,;72.87,-7.34,;74.21,-6.56,;74.21,-5.02,;75.54,-7.34,;75.7,-8.86,;77.21,-9.18,;77.98,-7.85,;76.95,-6.7,;79.51,-7.69,;80.41,-8.94,;81.94,-8.78,;82.57,-7.37,;81.66,-6.12,;80.13,-6.29,;72.88,-8.87,;74.21,-9.64,;71.55,-9.63,;71.55,-11.17,;72.89,-11.93,;74.22,-11.16,;75.55,-11.92,;72.89,-13.48,;71.55,-14.25,;70.22,-13.48,;70.22,-11.94,;68.89,-11.17,;67.55,-11.94,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.330	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production in...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00385 BindingDB Entry DOI: 10.7270/Q2M330MF
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM50577751 (CHEMBL4863297) Show SMILES CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2cccnc2)c(O)n1-c1c(OC)cccc1OC |(64.87,-8.89,;66.21,-9.66,;67.54,-8.88,;68.88,-9.65,;70.23,-8.88,;70.22,-7.35,;71.55,-6.58,;71.55,-5.02,;72.87,-7.34,;74.21,-6.56,;74.21,-5.02,;75.54,-7.34,;75.7,-8.86,;77.21,-9.18,;77.98,-7.85,;76.95,-6.7,;79.51,-7.69,;80.41,-8.94,;81.94,-8.78,;82.57,-7.37,;81.66,-6.12,;80.13,-6.29,;72.88,-8.87,;74.21,-9.64,;71.55,-9.63,;71.55,-11.17,;72.89,-11.93,;74.22,-11.16,;75.55,-11.92,;72.89,-13.48,;71.55,-14.25,;70.22,-13.48,;70.22,-11.94,;68.89,-11.17,;67.55,-11.94,)| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production ...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00385 BindingDB Entry DOI: 10.7270/Q2M330MF
					More data for this Ligand-Target Pair