null

SMILES: COc1cc2c3n(CC4CCOCC4)c(=O)[nH]c3cnc2cc1-c1c(C)noc1C

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50578795   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50578795 (CHEMBL4859880) Show SMILES COc1cc2c3n(CC4CCOCC4)c(=O)[nH]c3cnc2cc1-c1c(C)noc1C |(16.73,-29.9,;16.73,-31.44,;18.07,-32.21,;19.39,-31.44,;20.73,-32.2,;22.06,-31.43,;22.37,-29.93,;21.34,-28.79,;21.81,-27.32,;23.31,-27,;23.78,-25.54,;22.75,-24.39,;21.24,-24.71,;20.77,-26.18,;23.89,-29.76,;24.66,-28.43,;24.52,-31.16,;23.39,-32.19,;23.4,-33.74,;22.07,-34.51,;20.73,-33.75,;19.4,-34.52,;18.06,-33.75,;16.73,-34.52,;15.33,-33.9,;15.01,-32.39,;14.3,-35.04,;15.07,-36.38,;16.57,-36.06,;17.72,-37.09,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal 6His-tagged BRD4-BD1 Y390A mutant (1 to 477 residue) expressed in E...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00855 BindingDB Entry DOI: 10.7270/Q23T9N20
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50578795 (CHEMBL4859880) Show SMILES COc1cc2c3n(CC4CCOCC4)c(=O)[nH]c3cnc2cc1-c1c(C)noc1C |(16.73,-29.9,;16.73,-31.44,;18.07,-32.21,;19.39,-31.44,;20.73,-32.2,;22.06,-31.43,;22.37,-29.93,;21.34,-28.79,;21.81,-27.32,;23.31,-27,;23.78,-25.54,;22.75,-24.39,;21.24,-24.71,;20.77,-26.18,;23.89,-29.76,;24.66,-28.43,;24.52,-31.16,;23.39,-32.19,;23.4,-33.74,;22.07,-34.51,;20.73,-33.75,;19.4,-34.52,;18.06,-33.75,;16.73,-34.52,;15.33,-33.9,;15.01,-32.39,;14.3,-35.04,;15.07,-36.38,;16.57,-36.06,;17.72,-37.09,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of BRD4 in human PBMC assessed as reduction in LPS-induced IL-6 secretion incubated for 18 to 24 hrs by MSD assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00855 BindingDB Entry DOI: 10.7270/Q23T9N20
					More data for this Ligand-Target Pair