null

SMILES: COc1cc2c3n(Cc4ccccn4)c(nc3cnc2cc1-c1c(C)noc1C)C1CCOCC1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50578807   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50578807 (CHEMBL4855128) Show SMILES COc1cc2c3n(Cc4ccccn4)c(nc3cnc2cc1-c1c(C)noc1C)C1CCOCC1 |(3.21,-19.91,;3.21,-21.45,;4.54,-22.22,;5.87,-21.45,;7.2,-22.21,;8.53,-21.44,;8.84,-19.94,;7.81,-18.8,;8.28,-17.33,;9.78,-17.02,;10.26,-15.55,;9.22,-14.41,;7.71,-14.74,;7.25,-16.21,;10.37,-19.77,;11,-21.17,;9.86,-22.2,;9.88,-23.75,;8.54,-24.52,;7.21,-23.76,;5.87,-24.54,;4.54,-23.77,;3.2,-24.53,;1.8,-23.91,;1.48,-22.41,;.77,-25.06,;1.54,-26.39,;3.05,-26.07,;4.19,-27.1,;11.13,-18.44,;12.67,-18.43,;13.43,-17.1,;12.67,-15.77,;11.12,-15.77,;10.35,-17.11,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal 6His-tagged BRD4-BD1 Y390A mutant (1 to 477 residue) expressed in E...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00855 BindingDB Entry DOI: 10.7270/Q23T9N20
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50578807 (CHEMBL4855128) Show SMILES COc1cc2c3n(Cc4ccccn4)c(nc3cnc2cc1-c1c(C)noc1C)C1CCOCC1 |(3.21,-19.91,;3.21,-21.45,;4.54,-22.22,;5.87,-21.45,;7.2,-22.21,;8.53,-21.44,;8.84,-19.94,;7.81,-18.8,;8.28,-17.33,;9.78,-17.02,;10.26,-15.55,;9.22,-14.41,;7.71,-14.74,;7.25,-16.21,;10.37,-19.77,;11,-21.17,;9.86,-22.2,;9.88,-23.75,;8.54,-24.52,;7.21,-23.76,;5.87,-24.54,;4.54,-23.77,;3.2,-24.53,;1.8,-23.91,;1.48,-22.41,;.77,-25.06,;1.54,-26.39,;3.05,-26.07,;4.19,-27.1,;11.13,-18.44,;12.67,-18.43,;13.43,-17.1,;12.67,-15.77,;11.12,-15.77,;10.35,-17.11,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of BRD4 in human PBMC assessed as reduction in LPS-induced IL-6 secretion incubated for 18 to 24 hrs by MSD assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00855 BindingDB Entry DOI: 10.7270/Q23T9N20
					More data for this Ligand-Target Pair