null

SMILES: COCC(C)n1c(COC)nc2cnc3cc(-c4c(C)noc4C)c(OC)cc3c12

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50578808   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50578808 (CHEMBL4862100) Show SMILES COCC(C)n1c(COC)nc2cnc3cc(-c4c(C)noc4C)c(OC)cc3c12 |(22.07,-16.23,;21.6,-17.7,;20.09,-18.03,;19.62,-19.49,;18.12,-19.82,;20.66,-20.63,;22.18,-20.47,;22.95,-19.13,;24.49,-19.13,;25.25,-17.79,;22.81,-21.87,;21.67,-22.89,;21.69,-24.44,;20.35,-25.22,;19.02,-24.45,;17.69,-25.23,;16.35,-24.46,;15.02,-25.23,;13.62,-24.6,;13.3,-23.1,;12.58,-25.75,;13.35,-27.08,;14.86,-26.76,;16.01,-27.79,;16.35,-22.91,;15.02,-22.14,;15.02,-20.6,;17.68,-22.14,;19.02,-22.91,;20.34,-22.13,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal 6His-tagged BRD4-BD1 Y390A mutant (1 to 477 residue) expressed in E...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00855 BindingDB Entry DOI: 10.7270/Q23T9N20
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50578808 (CHEMBL4862100) Show SMILES COCC(C)n1c(COC)nc2cnc3cc(-c4c(C)noc4C)c(OC)cc3c12 |(22.07,-16.23,;21.6,-17.7,;20.09,-18.03,;19.62,-19.49,;18.12,-19.82,;20.66,-20.63,;22.18,-20.47,;22.95,-19.13,;24.49,-19.13,;25.25,-17.79,;22.81,-21.87,;21.67,-22.89,;21.69,-24.44,;20.35,-25.22,;19.02,-24.45,;17.69,-25.23,;16.35,-24.46,;15.02,-25.23,;13.62,-24.6,;13.3,-23.1,;12.58,-25.75,;13.35,-27.08,;14.86,-26.76,;16.01,-27.79,;16.35,-22.91,;15.02,-22.14,;15.02,-20.6,;17.68,-22.14,;19.02,-22.91,;20.34,-22.13,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of BRD4 in human PBMC assessed as reduction in LPS-induced IL-6 secretion incubated for 18 to 24 hrs by MSD assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00855 BindingDB Entry DOI: 10.7270/Q23T9N20
					More data for this Ligand-Target Pair