null

SMILES: COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC)cc3c2n1CC1CCOCC1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50578809   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50578809 (CHEMBL4875479) Show SMILES COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC)cc3c2n1CC1CCOCC1 |(35.93,-21.22,;35.15,-19.89,;33.61,-19.89,;32.85,-21.23,;33.47,-22.63,;32.34,-23.66,;32.35,-25.21,;31.02,-25.98,;29.68,-25.21,;28.35,-25.99,;27.02,-25.22,;25.68,-25.99,;24.28,-25.37,;23.96,-23.86,;23.25,-26.51,;24.02,-27.85,;25.52,-27.53,;26.67,-28.56,;27.02,-23.68,;25.68,-22.91,;25.68,-21.37,;28.35,-22.91,;29.68,-23.67,;31.01,-22.9,;31.32,-21.4,;30.29,-20.25,;30.76,-18.79,;32.26,-18.47,;32.74,-17.01,;31.71,-15.87,;30.2,-16.19,;29.72,-17.66,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal 6His-tagged BRD4-BD1 Y390A mutant (1 to 477 residue) expressed in E...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00855 BindingDB Entry DOI: 10.7270/Q23T9N20
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50578809 (CHEMBL4875479) Show SMILES COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC)cc3c2n1CC1CCOCC1 |(35.93,-21.22,;35.15,-19.89,;33.61,-19.89,;32.85,-21.23,;33.47,-22.63,;32.34,-23.66,;32.35,-25.21,;31.02,-25.98,;29.68,-25.21,;28.35,-25.99,;27.02,-25.22,;25.68,-25.99,;24.28,-25.37,;23.96,-23.86,;23.25,-26.51,;24.02,-27.85,;25.52,-27.53,;26.67,-28.56,;27.02,-23.68,;25.68,-22.91,;25.68,-21.37,;28.35,-22.91,;29.68,-23.67,;31.01,-22.9,;31.32,-21.4,;30.29,-20.25,;30.76,-18.79,;32.26,-18.47,;32.74,-17.01,;31.71,-15.87,;30.2,-16.19,;29.72,-17.66,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	398	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of BRD4 in human PBMC assessed as reduction in LPS-induced IL-6 secretion incubated for 18 to 24 hrs by MSD assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00855 BindingDB Entry DOI: 10.7270/Q23T9N20
					More data for this Ligand-Target Pair