null

SMILES: CCOc1ccc(nc1)-c1nnc([C@H]2C[C@@H](C2)NC(=O)c2ccnc3cc(F)cnc23)n1-c1cccnc1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50579965   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50579965 (CHEMBL5078858 | US11926614, Example 164) Show SMILES CCOc1ccc(nc1)-c1nnc([C@H]2C[C@@H](C2)NC(=O)c2ccnc3cc(F)cnc23)n1-c1cccnc1 |r,wU:15.18,wD:13.13,(54.53,-12.18,;55.16,-13.59,;56.69,-13.75,;57.59,-12.51,;59.13,-12.67,;60.03,-11.43,;59.4,-10.03,;57.87,-9.86,;56.97,-11.1,;60.3,-8.79,;59.83,-7.32,;61.07,-6.41,;62.33,-7.32,;63.79,-6.84,;65.17,-7.54,;65.87,-6.17,;64.5,-5.46,;67.34,-5.69,;67.67,-4.18,;66.52,-3.14,;69.14,-3.7,;69.45,-2.19,;70.91,-1.71,;72.07,-2.74,;71.75,-4.26,;72.89,-5.28,;72.58,-6.79,;73.72,-7.81,;71.1,-7.27,;69.96,-6.23,;70.28,-4.73,;61.85,-8.79,;62.75,-10.03,;62.12,-11.43,;63.02,-12.68,;64.55,-12.52,;65.18,-11.1,;64.27,-9.87,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50579965 (CHEMBL5078858 | US11926614, Example 164) Show SMILES CCOc1ccc(nc1)-c1nnc([C@H]2C[C@@H](C2)NC(=O)c2ccnc3cc(F)cnc23)n1-c1cccnc1 |r,wU:15.18,wD:13.13,(54.53,-12.18,;55.16,-13.59,;56.69,-13.75,;57.59,-12.51,;59.13,-12.67,;60.03,-11.43,;59.4,-10.03,;57.87,-9.86,;56.97,-11.1,;60.3,-8.79,;59.83,-7.32,;61.07,-6.41,;62.33,-7.32,;63.79,-6.84,;65.17,-7.54,;65.87,-6.17,;64.5,-5.46,;67.34,-5.69,;67.67,-4.18,;66.52,-3.14,;69.14,-3.7,;69.45,-2.19,;70.91,-1.71,;72.07,-2.74,;71.75,-4.26,;72.89,-5.28,;72.58,-6.79,;73.72,-7.81,;71.1,-7.27,;69.96,-6.23,;70.28,-4.73,;61.85,-8.79,;62.75,-10.03,;62.12,-11.43,;63.02,-12.68,;64.55,-12.52,;65.18,-11.1,;64.27,-9.87,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human TNKS2 (873 to 1162 residues) incubated for 20 hrs in presence of NAD				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01264 BindingDB Entry DOI: 10.7270/Q21R6VDH
					More data for this Ligand-Target Pair