null
SMILES: Cn1c(Nc2ccc(cc2)C(=O)N[C@@H](CC(O)=O)C(O)=O)nc2n(C)c(=O)n(Cc3ccc(Cl)c(Cl)c3)c(=O)c12
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-1-tetrahydrofolate synthase, cytoplasmic (Homo sapiens) | BDBM50580115 (CHEMBL5084848) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00663 BindingDB Entry DOI: 10.7270/Q2B56PKM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (Homo sapiens (Human)) | BDBM50580115 (CHEMBL5084848) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of C-terminal His-tagged human MTHFD2 (36 to 350 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00663 BindingDB Entry DOI: 10.7270/Q2B56PKM | |||||||||||
More data for this Ligand-Target Pair |