null
SMILES: OC(=O)c1cnc(SCC(=O)c2ccccc2)[nH]c1=O
InChI Key:
PDB links: 1 PDB ID matches this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hypoxia-inducible factor 1-alpha inhibitor (Homo sapiens (Human)) | BDBM50580324![]() (CHEMBL5081435) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 2A (Homo sapiens (Human)) | BDBM50580324![]() (CHEMBL5081435) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 4.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human N-terminal His6-tagged KDM2A (M1 to P517 residues) expressed in insect cells using H3K36(Me2) as substrate preincubated for 15 mi... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 3B (Homo sapiens (Human)) | BDBM50580324![]() (CHEMBL5081435) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 5.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human N-terminal His6-tagged KDM3B (L882 to S1761 residues) expressed in insect cells using H3K9(Me2) as substrate preincubated for 15 ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 6B (Homo sapiens (Human)) | BDBM50580324![]() (CHEMBL5081435) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 4.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human KDM6B (D1141 to R1641 residues) expressed in Escherichia coli using H3K27(Me3) as substrate preincubated for 15 mins followed by ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4D (Homo sapiens (Human)) | BDBM50580324![]() (CHEMBL5081435) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 2.67E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human N-terminal His6-tagged KDM4D (M1 to G373 residues) expressed in Escherichia coli using H3K9(Me3) as substrate preincubated for 15... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM50580324![]() (CHEMBL5081435) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 4.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human N-terminal His6-tagged KDM5B (L882 to S1761 residues) expressed in insect cells using H3K4(Me3) as substrate preincubated for 15 ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Lysine-specific demethylase 4A (Homo sapiens (Human)) | BDBM50580324![]() (CHEMBL5081435) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 3.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human N-terminal His6-tagged KDM4A (M1 to L359 residues) expressed in Escherichia coli using H3K9(Me3) as substrate preincubated for 15... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00605 BindingDB Entry DOI: 10.7270/Q2GQ72N6 | |||||||||||
More data for this Ligand-Target Pair |