null
SMILES: COC(=O)c1ccc(CCNC(=N)N\N=C\c2c[nH]c3c(C)cc(cc23)C#N)cc1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Relaxin-3 receptor 1 (Homo sapiens (Human)) | BDBM50581019![]() (CHEMBL5089949) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | 69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I]R3/I5 from human RXFP3 expressed in human CHO-K1 cells incubated for 1 hr by microplate scintillation counting analysis | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01081 BindingDB Entry DOI: 10.7270/Q2ZK5MJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Relaxin-3 receptor 2 (Homo sapiens (Human)) | BDBM50581019![]() (CHEMBL5089949) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human RXFP4 expressed in human CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 1.5 hrs ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01081 BindingDB Entry DOI: 10.7270/Q2ZK5MJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Relaxin-3 receptor 1 (Homo sapiens (Human)) | BDBM50581019![]() (CHEMBL5089949) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 1.5 hrs ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01081 BindingDB Entry DOI: 10.7270/Q2ZK5MJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Relaxin-3 receptor 1 (Homo sapiens (Human)) | BDBM50581019![]() (CHEMBL5089949) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as beta arrestin-2 recruitment measured after 4 hrs by beta-galactosidase ba... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01081 BindingDB Entry DOI: 10.7270/Q2ZK5MJP | |||||||||||
More data for this Ligand-Target Pair |