null

SMILES: Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50584871   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Stimulator of interferon genes protein (Human)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Mus musculus)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in mouse RAW-Lucia ISG cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene ass...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in human THP1 Dual KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gen...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Mus musculus)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in mouse RAW-Lucia ISG-KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene a...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Mus musculus)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	940	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescein-labelled probe from wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Mus musculus)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescein-labelled probe from wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescein-labelled probe from human cytoplasmic domain of STING G230A/R293Q double mutant (155 to 341 residues) by time-resolved FR...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human STING G230A/R293Q double mutant cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incu...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584871 (CHEMBL5080916) Show SMILES Clc1cc2cc(CNC(=O)c3cnn4cccnc34)oc2c2c1oc(=O)[nH]c2=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in human THP1-Dual KO-STING cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP report...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair