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null

SMILES: C[C@H](NC(=O)c1cnn2cccnc12)c1cc2cc(Cl)cc(C(O)=O)c2o1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50584879
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Stimulator of interferon genes protein (Human)	BDBM50584879 (CHEMBL5092039) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescein-labelled probe from wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
TBA					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Mus musculus)	BDBM50584879 (CHEMBL5092039) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescein-labelled probe from wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
TBA					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Mus musculus)	BDBM50584879 (CHEMBL5092039) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
TBA					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584879 (CHEMBL5092039) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
TBA					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584879 (CHEMBL5092039) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.40E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human STING G230A/R293Q double mutant cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incu...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
TBA					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584879 (CHEMBL5092039) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescein-labelled probe from human cytoplasmic domain of STING G230A/R293Q double mutant (155 to 341 residues) by time-resolved FR...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
TBA					More data for this Ligand-Target Pair