BindingDB PrimarySearch_ki

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Enter Data

null

SMILES: COc1cc(N(C)CCN(C)Cc2ccccc2)c(NC(=O)C=C)cc1Nc1nccc(Nc2cn(C)c3ccccc23)n1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50585308
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50585308 (CHEMBL5089161) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of EGFR del19 (unknown origin) using flurogenic substrate in presence of ATP by HTRF assay				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113984 BindingDB Entry DOI: 10.7270/Q2M330PB
TBA					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50585308 (CHEMBL5089161) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	406	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of wild type EGFR (unknown origin) using flurogenic substrate in presence of ATP by HTRF assay				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113984 BindingDB Entry DOI: 10.7270/Q2M330PB
TBA					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50585308 (CHEMBL5089161) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of EGFR T790M/C797S double mutant (unknown origin) using flurogenic substrate in presence of ATP by HTRF assay				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113984 BindingDB Entry DOI: 10.7270/Q2M330PB
TBA					More data for this Ligand-Target Pair