null

SMILES: CN1CCC(CC1)Oc1ccc2cnc(Nc3ccc(cc3F)-n3ccc(CO)n3)cc2n1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50585754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50585754 (CHEMBL5093640) Show SMILES CN1CCC(CC1)Oc1ccc2cnc(Nc3ccc(cc3F)-n3ccc(CO)n3)cc2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of full length N-terminal GST tagged human CDK2(1 to 298 residues)/CyclinA2 (1 to 432 residues) expressed in baculovirus expression system...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02069 BindingDB Entry DOI: 10.7270/Q2CF9V08
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50585754 (CHEMBL5093640) Show SMILES CN1CCC(CC1)Oc1ccc2cnc(Nc3ccc(cc3F)-n3ccc(CO)n3)cc2n1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02069 BindingDB Entry DOI: 10.7270/Q2CF9V08
					More data for this Ligand-Target Pair