null
SMILES: CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3ccc(cc3F)C#N)cc2n1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM50585774 (CHEMBL5086375) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of full length N-terminal GST tagged human CDK2(1 to 298 residues)/CyclinA2 (1 to 432 residues) expressed in baculovirus expression system... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02069 BindingDB Entry DOI: 10.7270/Q2CF9V08 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human)) | BDBM50585774 (CHEMBL5086375) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02069 BindingDB Entry DOI: 10.7270/Q2CF9V08 | |||||||||||
More data for this Ligand-Target Pair |