null

SMILES: Cc1ccc2[nH]ncc2c1-c1c(Cl)cc2c(nc(OCCCN3CCCCC3)nc2c1F)N1CCC2(CN(C2)C(=O)C=C)CC1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50590545   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GTPase KRas (Homo sapiens (Human))	BDBM50590545 (CHEMBL5206689) Show SMILES Cc1ccc2[nH]ncc2c1-c1c(Cl)cc2c(nc(OCCCN3CCCCC3)nc2c1F)N1CCC2(CN(C2)C(=O)C=C)CC1 |(-4.76,-8.02,;-6.09,-7.25,;-7.42,-8.02,;-8.76,-7.26,;-8.76,-5.72,;-9.9,-4.68,;-9.27,-3.28,;-7.74,-3.44,;-7.42,-4.95,;-6.09,-5.71,;-4.76,-4.94,;-4.76,-3.4,;-6.09,-2.63,;-3.43,-2.64,;-2.09,-3.41,;-.77,-2.64,;.56,-3.41,;.56,-4.93,;1.9,-5.7,;3.23,-4.93,;4.56,-5.7,;5.9,-4.93,;7.23,-5.7,;8.57,-4.93,;9.9,-5.7,;9.9,-7.24,;8.57,-8.01,;7.23,-7.24,;-.76,-5.71,;-2.09,-4.94,;-3.42,-5.72,;-3.42,-7.26,;-.77,-1.1,;-2.11,-.33,;-2.11,1.21,;-.77,1.98,;-1.88,3.09,;-.79,4.17,;.32,3.07,;-.79,5.71,;-2.12,6.48,;.54,6.48,;.54,8.02,;.56,1.21,;.56,-.33,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116949 BindingDB Entry DOI: 10.7270/Q23T9N5B
					More data for this Ligand-Target Pair