BDBM50716 (8R)-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl]-7-(1-oxo-2,2-diphenylethyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide::(8R)-7-(2,2-diphenylacetyl)-3-(3-methacrylamidophenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide::(8R)-7-(2,2-diphenylacetyl)-3-[3-(2-methylprop-2-enoylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide::(8R)-7-(2,2-diphenylethanoyl)-3-[3-(2-methylprop-2-enoylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide::MLS000562003::SMR000390651::cid_16745486

SMILES: CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)C(c2ccccc2)c2ccccc2)C(N)=O)C1

InChI Key: InChIKey=QRKKRZLARXFWKP-SYQKMTEESA-N

Data: 2 IC50  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50716   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM50716 ((8R)-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)C(c2ccccc2)c2ccccc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C31H30N4O4/c1-20(2)29(37)33-24-15-9-14-23(16-24)25-17-31(39-34-25)18-26(28(32)36)35(19-31)30(38)27(21-10-5-3-6-11-21)22-12-7-4-8-13-22/h3-16,26-27H,1,17-19H2,2H3,(H2,32,36)(H,33,37)/t26-,31?/m1/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	3.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay					Assay Description NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q23X8539
					More data for this Ligand-Target Pair
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human))	BDBM50716 ((8R)-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)C(c2ccccc2)c2ccccc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C31H30N4O4/c1-20(2)29(37)33-24-15-9-14-23(16-24)25-17-31(39-34-25)18-26(28(32)36)35(19-31)30(38)27(21-10-5-3-6-11-21)22-12-7-4-8-13-22/h3-16,26-27H,1,17-19H2,2H3,(H2,32,36)(H,33,37)/t26-,31?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	8.59E+4	n/a	n/a	n/a	n/a
NMMLSC Curated by PubChem BioAssay					Assay Description University of New Mexico Assay Overview: Assay Support: 1 R03 DA030557-01A1 Project Title: RNA Aptamer-based screen for Selective Inhibitors of ...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2B56H72
					More data for this Ligand-Target Pair
Apoptotic peptidase activating factor 1 (Homo sapiens (Human))	BDBM50716 ((8R)-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)C(c2ccccc2)c2ccccc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C31H30N4O4/c1-20(2)29(37)33-24-15-9-14-23(16-24)25-17-31(39-34-25)18-26(28(32)36)35(19-31)30(38)27(21-10-5-3-6-11-21)22-12-7-4-8-13-22/h3-16,26-27H,1,17-19H2,2H3,(H2,32,36)(H,33,37)/t26-,31?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q29C6VXX
					More data for this Ligand-Target Pair
Apoptotic peptidase activating factor 1 (Homo sapiens (Human))	BDBM50716 ((8R)-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)C(c2ccccc2)c2ccccc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C31H30N4O4/c1-20(2)29(37)33-24-15-9-14-23(16-24)25-17-31(39-34-25)18-26(28(32)36)35(19-31)30(38)27(21-10-5-3-6-11-21)22-12-7-4-8-13-22/h3-16,26-27H,1,17-19H2,2H3,(H2,32,36)(H,33,37)/t26-,31?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2SB447H
					More data for this Ligand-Target Pair
Caspase-9 (Homo sapiens (Human))	BDBM50716 ((8R)-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)C(c2ccccc2)c2ccccc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C31H30N4O4/c1-20(2)29(37)33-24-15-9-14-23(16-24)25-17-31(39-34-25)18-26(28(32)36)35(19-31)30(38)27(21-10-5-3-6-11-21)22-12-7-4-8-13-22/h3-16,26-27H,1,17-19H2,2H3,(H2,32,36)(H,33,37)/t26-,31?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	6.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q25M647F
					More data for this Ligand-Target Pair