null

SMILES: CC(C)n1cnc2cc(nc(Nc3ccncc3F)c12)-c1ccc2c(c1)N(C1CC(C1)N1CC3CCC(C3)C1)C(=O)C21CCN(CC1)C(=O)C1CCO1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 509018   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM509018 (US11071730, Example 125) Show SMILES CC(C)n1cnc2cc(nc(Nc3ccncc3F)c12)-c1ccc2c(c1)N(C1CC(C1)N1CC3CCC(C3)C1)C(=O)C21CCN(CC1)C(=O)C1CCO1 |(10.16,-3.43,;8.64,-3.66,;8.07,-5.09,;7.68,-2.45,;8.1,-.97,;6.81,-.11,;5.61,-1.07,;4.09,-.81,;3.11,-2,;3.64,-3.44,;5.16,-3.7,;5.7,-5.14,;4.72,-6.33,;5.25,-7.77,;4.27,-8.96,;2.75,-8.7,;2.22,-7.26,;3.2,-6.07,;2.66,-4.63,;6.14,-2.51,;1.59,-1.74,;.61,-2.93,;-.91,-2.67,;-1.45,-1.23,;-.47,-.04,;1.05,-.3,;-1.29,1.26,;-.72,2.69,;-1.33,4.1,;.08,4.72,;.69,3.3,;.65,6.15,;-.26,7.39,;.37,8.8,;.53,7.27,;1.54,6.87,;2.8,7.71,;1.9,8.96,;2.18,6.31,;-2.78,.88,;-3.97,1.86,;-2.88,-.66,;-2.82,-2.2,;-4.12,-3.02,;-5.48,-2.31,;-5.54,-.77,;-4.24,.05,;-6.78,-3.13,;-6.72,-4.67,;-8.15,-2.42,;-9.65,-2.74,;-10.3,-1.17,;-8.77,-1.01,)| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant HPK1 kinase domain produced via baculovirus infection of insect cells was obtained from Proteros (Proteros Biostructures #PR-0322) and wa...				Citation and Details BindingDB Entry DOI: 10.7270/Q2RR22CJ
					More data for this Ligand-Target Pair