BDBM5095 1,2,4-Oxadiazole Analogue 5d::4-[(2S)-2-{[(1S)-1-{3-[(3,4-dichlorophenyl)methyl]-1,2,4-oxadiazol-5-yl}ethyl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid::CHEMBL318300
SMILES: C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc(Cl)c(Cl)c2)no1
InChI Key: InChIKey=CBNCEXIXRUFMGU-BUXKBTBVSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human)) | BDBM5095![]() (1,2,4-Oxadiazole Analogue 5d | 4-[(2S)-2-{[(1S)-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals, Inc. | Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference... | J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM5095![]() (1,2,4-Oxadiazole Analogue 5d | 4-[(2S)-2-{[(1S)-1-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals, Inc. | Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference... | J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM5095![]() (1,2,4-Oxadiazole Analogue 5d | 4-[(2S)-2-{[(1S)-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals, Inc. | Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference... | J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human)) | BDBM5095![]() (1,2,4-Oxadiazole Analogue 5d | 4-[(2S)-2-{[(1S)-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Affinity for Zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70) | Bioorg Med Chem Lett 9: 3009-14 (1999) BindingDB Entry DOI: 10.7270/Q2ZS2VQR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM5095![]() (1,2,4-Oxadiazole Analogue 5d | 4-[(2S)-2-{[(1S)-1-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Affinity for Src protein tryrosine kinase | Bioorg Med Chem Lett 9: 3009-14 (1999) BindingDB Entry DOI: 10.7270/Q2ZS2VQR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM5095![]() (1,2,4-Oxadiazole Analogue 5d | 4-[(2S)-2-{[(1S)-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Affinity for Syk protein tyrosine kinase | Bioorg Med Chem Lett 9: 3009-14 (1999) BindingDB Entry DOI: 10.7270/Q2ZS2VQR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Grb2-SH2 (Homo sapiens (Human)) | BDBM5095![]() (1,2,4-Oxadiazole Analogue 5d | 4-[(2S)-2-{[(1S)-1-...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals, Inc. | Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference... | J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP | |||||||||||
More data for this Ligand-Target Pair |