BDBM5106 1,2,4-Oxadiazole Analogue 15c::4-[(2S)-2-{[(1S)-2-hydroxy-1-[3-(naphthalen-2-ylmethyl)-1,2,4-oxadiazol-5-yl]ethyl]carbamoyl}-2-(1-phenylacetamido)ethyl]phenoxyphosphonic acid

SMILES: OC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc3ccccc3c2)no1

InChI Key: InChIKey=RRNYTUGEKKWGTI-NSOVKSMOSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 5106   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5106 (1,2,4-Oxadiazole Analogue 15c | 4-[(2S)-2-{[(1S)-2...) Show SMILES OC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc3ccccc3c2)no1 |r| Show InChI InChI=1S/C32H31N4O8P/c37-20-28(32-35-29(36-43-32)18-23-10-13-24-8-4-5-9-25(24)16-23)34-31(39)27(33-30(38)19-21-6-2-1-3-7-21)17-22-11-14-26(15-12-22)44-45(40,41)42/h1-16,27-28,37H,17-20H2,(H,33,38)(H,34,39)(H2,40,41,42)/t27-,28-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM5106 (1,2,4-Oxadiazole Analogue 15c | 4-[(2S)-2-{[(1S)-2...) Show SMILES OC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc3ccccc3c2)no1 |r| Show InChI InChI=1S/C32H31N4O8P/c37-20-28(32-35-29(36-43-32)18-23-10-13-24-8-4-5-9-25(24)16-23)34-31(39)27(33-30(38)19-21-6-2-1-3-7-21)17-22-11-14-26(15-12-22)44-45(40,41)42/h1-16,27-28,37H,17-20H2,(H,33,38)(H,34,39)(H2,40,41,42)/t27-,28-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Grb2-SH2 (Homo sapiens (Human))	BDBM5106 (1,2,4-Oxadiazole Analogue 15c | 4-[(2S)-2-{[(1S)-2...) Show SMILES OC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc3ccccc3c2)no1 |r| Show InChI InChI=1S/C32H31N4O8P/c37-20-28(32-35-29(36-43-32)18-23-10-13-24-8-4-5-9-25(24)16-23)34-31(39)27(33-30(38)19-21-6-2-1-3-7-21)17-22-11-14-26(15-12-22)44-45(40,41)42/h1-16,27-28,37H,17-20H2,(H,33,38)(H,34,39)(H2,40,41,42)/t27-,28-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.68E+5	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM5106 (1,2,4-Oxadiazole Analogue 15c | 4-[(2S)-2-{[(1S)-2...) Show SMILES OC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc3ccccc3c2)no1 |r| Show InChI InChI=1S/C32H31N4O8P/c37-20-28(32-35-29(36-43-32)18-23-10-13-24-8-4-5-9-25(24)16-23)34-31(39)27(33-30(38)19-21-6-2-1-3-7-21)17-22-11-14-26(15-12-22)44-45(40,41)42/h1-16,27-28,37H,17-20H2,(H,33,38)(H,34,39)(H2,40,41,42)/t27-,28-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair