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SMILES: CN1CCN(CCCNC(=O)C[C@@H]2N=C(c3c(C)c(sc3-n3c(C)nnc23)C(=O)NCCCCCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c2ccc(Cl)cc2)CC1

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 511623   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA damage-binding protein 1/Protein cereblon


(Homo sapiens (Human))		BDBM511623
PNG
(US11059801, Compound dBET31)
Show SMILES CN1CCN(CCCNC(=O)C[C@@H]2N=C(c3c(C)c(sc3-n3c(C)nnc23)C(=O)NCCCCCCCCNC(=O)COc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)c2ccc(Cl)cc2)CC1 |r,c:13|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 26.8n/an/an/an/an/an/a


TBA

Assay Description
A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2G44TFM
More data for this
Ligand-Target Pair