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SMILES: Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCNC(=O)CNc1cccc3C(=O)N(Cc13)C1CCC(=O)NC1=O)c1nnc(C)n-21)c1ccc(Cl)cc1

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 511627   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon


(Homo sapiens (Human))		BDBM511627
PNG
(US11059801, Compound dBET35)
Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCNC(=O)CNc1cccc3C(=O)N(Cc13)C1CCC(=O)NC1=O)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.21n/an/an/an/an/an/a


TBA

Assay Description
AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2G44TFM
More data for this
Ligand-Target Pair