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SMILES: O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(NCc3ccco3)ccc12

InChI Key:

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 511661   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA damage-binding protein 1/Protein cereblon


(Homo sapiens (Human))		BDBM511661
PNG
(US11059801, Compound D-28)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(NCc3ccco3)ccc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40.1n/an/an/an/an/an/a


TBA

Assay Description
A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2G44TFM
More data for this
Ligand-Target Pair