null
SMILES: Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C(N)=O)n(C)n1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human)) | BDBM513649![]() (8-(1,3-dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description An aliquot of each serial dilution of test compound was added to deep 384 well plate using Acoustic Technology instrument (Echo 550, LabCyte) contain... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HQ43R4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human)) | BDBM513649![]() (8-(1,3-dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1... | Citation and Details BindingDB Entry DOI: 10.7270/Q2V69NQ4 | |||||||||||
More data for this Ligand-Target Pair |