null
SMILES: Nc1nn2ccc3nc2c1C(=O)NCCOc1ccc(F)cc1[C@H]1CCCN31
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM515350 ((R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the... | Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor [G595R] (Homo sapiens (Human)) | BDBM515350 ((R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.08 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human)) | BDBM515350 ((R,13E,14E)-12-amino-35-fluro-4-oxa-7-aza- 1(5,3)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.63 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c... | Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK | |||||||||||
More data for this Ligand-Target Pair |