null
SMILES: Nc1nn2ccc3nc2c1C(=O)NCCCOc1ncc(F)cc1C1C[C@@H](F)CN31
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity nerve growth factor receptor [G667C] (Homo sapiens (Human)) | BDBM515355 ((13E,14E, 22R,24R)-12-amino-24,35- difluoro-4-oxa-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c... | Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM515355 ((13E,14E, 22R,24R)-12-amino-24,35- difluoro-4-oxa-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the... | Citation and Details BindingDB Entry DOI: 10.7270/Q22N55FK | |||||||||||
More data for this Ligand-Target Pair |