null
SMILES: Cc1ccc(c(F)c1)C1=C(c2cnc(O[C@H]3CCN(CCCF)C3)nc2)c2ccc(O)cc2CCC1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521420 (6-(2-fluoro-4- methyl-phenyl)- 5-[2-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554,Y537S] (Homo sapiens (Human)) | BDBM521420 (6-(2-fluoro-4- methyl-phenyl)- 5-[2-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554,D538G] (Homo sapiens (Human)) | BDBM521420 (6-(2-fluoro-4- methyl-phenyl)- 5-[2-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair |