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SMILES: Cc1nc(cc(n1)-n1ncc2c(F)cc(cc12)C1(CC11CC1)C#N)N1CC2(CC1C2)C(C)(C)O

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 523092   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 [1-1200,1251-2527,G2019S]


(Homo sapiens (Human))		BDBM523092
PNG
(US11161854, Example 4.16)
Show SMILES Cc1nc(cc(n1)-n1ncc2c(F)cc(cc12)C1(CC11CC1)C#N)N1CC2(CC1C2)C(C)(C)O |(-1.92,-4.77,;-.88,-3.63,;.62,-3.95,;1.65,-2.8,;1.18,-1.34,;-.33,-1.02,;-1.36,-2.16,;-.81,.45,;.1,1.69,;-.81,2.94,;-2.27,2.46,;-3.6,3.23,;-3.6,4.77,;-4.94,2.46,;-4.94,.92,;-3.6,.15,;-2.27,.92,;-6.27,.15,;-7.04,-1.18,;-5.5,-1.18,;-4.73,-2.52,;-3.96,-1.18,;-7.36,1.24,;-8.45,2.33,;3.16,-3.12,;4.3,-2.09,;5.64,-2.86,;5.32,-4.37,;3.78,-4.53,;4.55,-3.2,;7.04,-2.24,;8.29,-3.14,;7.2,-.71,;8.45,-1.61,)|
PDB

UniProtKB/SwissProt

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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a


TBA

Assay Description
The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, C...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29K4FC3
More data for this
Ligand-Target Pair