null

SMILES: O[C@H]1CC[C@H](CC1)n1c2ccccc2[nH]\c1=N/C(=O)c1ccnc(c1)-c1ccccc1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 525470   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [695-1022,T790M,C797S,L858R] (Homo sapiens (Human))	BDBM525470 (US11174245, # I-107) Show SMILES O[C@H]1CC[C@H](CC1)n1c2ccccc2[nH]\c1=N/C(=O)c1ccnc(c1)-c1ccccc1 |r,wU:4.7,1.0,(-1.41,-4.93,;-1.81,-3.44,;-3.3,-3.05,;-3.7,-1.56,;-2.61,-.47,;-1.12,-.87,;-.72,-2.36,;-3.01,1.02,;-4.47,1.49,;-5.8,.72,;-7.14,1.49,;-7.14,3.03,;-5.8,3.8,;-4.47,3.03,;-3.01,3.51,;-2.1,2.26,;-.56,2.26,;.21,3.6,;-.56,4.93,;1.75,3.6,;2.52,4.93,;4.06,4.93,;4.83,3.6,;4.06,2.26,;2.52,2.26,;4.83,.93,;4.06,-.4,;4.83,-1.74,;6.37,-1.74,;7.14,-.4,;6.37,.93,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [695-1022] (Homo sapiens (Human))	BDBM525470 (US11174245, # I-107) Show SMILES O[C@H]1CC[C@H](CC1)n1c2ccccc2[nH]\c1=N/C(=O)c1ccnc(c1)-c1ccccc1 |r,wU:4.7,1.0,(-1.41,-4.93,;-1.81,-3.44,;-3.3,-3.05,;-3.7,-1.56,;-2.61,-.47,;-1.12,-.87,;-.72,-2.36,;-3.01,1.02,;-4.47,1.49,;-5.8,.72,;-7.14,1.49,;-7.14,3.03,;-5.8,3.8,;-4.47,3.03,;-3.01,3.51,;-2.1,2.26,;-.56,2.26,;.21,3.6,;-.56,4.93,;1.75,3.6,;2.52,4.93,;4.06,4.93,;4.83,3.6,;4.06,2.26,;2.52,2.26,;4.83,.93,;4.06,-.4,;4.83,-1.74,;6.37,-1.74,;7.14,-.4,;6.37,.93,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [695-1022] (Homo sapiens (Human))	BDBM525470 (US11174245, # I-107) Show SMILES O[C@H]1CC[C@H](CC1)n1c2ccccc2[nH]\c1=N/C(=O)c1ccnc(c1)-c1ccccc1 |r,wU:4.7,1.0,(-1.41,-4.93,;-1.81,-3.44,;-3.3,-3.05,;-3.7,-1.56,;-2.61,-.47,;-1.12,-.87,;-.72,-2.36,;-3.01,1.02,;-4.47,1.49,;-5.8,.72,;-7.14,1.49,;-7.14,3.03,;-5.8,3.8,;-4.47,3.03,;-3.01,3.51,;-2.1,2.26,;-.56,2.26,;.21,3.6,;-.56,4.93,;1.75,3.6,;2.52,4.93,;4.06,4.93,;4.83,3.6,;4.06,2.26,;2.52,2.26,;4.83,.93,;4.06,-.4,;4.83,-1.74,;6.37,-1.74,;7.14,-.4,;6.37,.93,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	336	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [695-1022,T790M,C797S,L858R] (Homo sapiens (Human))	BDBM525470 (US11174245, # I-107) Show SMILES O[C@H]1CC[C@H](CC1)n1c2ccccc2[nH]\c1=N/C(=O)c1ccnc(c1)-c1ccccc1 |r,wU:4.7,1.0,(-1.41,-4.93,;-1.81,-3.44,;-3.3,-3.05,;-3.7,-1.56,;-2.61,-.47,;-1.12,-.87,;-.72,-2.36,;-3.01,1.02,;-4.47,1.49,;-5.8,.72,;-7.14,1.49,;-7.14,3.03,;-5.8,3.8,;-4.47,3.03,;-3.01,3.51,;-2.1,2.26,;-.56,2.26,;.21,3.6,;-.56,4.93,;1.75,3.6,;2.52,4.93,;4.06,4.93,;4.83,3.6,;4.06,2.26,;2.52,2.26,;4.83,.93,;4.06,-.4,;4.83,-1.74,;6.37,-1.74,;7.14,-.4,;6.37,.93,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair