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SMILES: Cc1cc(cc(n1)-c1cnn(C)c1)C(=O)\N=c1/[nH]c2ccccc2n1[C@@H]1CC[C@H](O)CC1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 525490   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [695-745,751-1022,T790M,C797S] (Homo sapiens (Human))	BDBM525490 (US11174245, # I-143) Show SMILES Cc1cc(cc(n1)-c1cnn(C)c1)C(=O)\N=c1/[nH]c2ccccc2n1[C@@H]1CC[C@H](O)CC1 |r,wU:25.28,28.32,(4.98,5.6,;4.21,4.26,;2.67,4.26,;1.9,2.93,;2.67,1.6,;4.21,1.6,;4.98,2.93,;4.98,.26,;6.52,.26,;6.99,-1.2,;5.75,-2.11,;5.75,-3.65,;4.5,-1.2,;.36,2.93,;-.41,4.26,;-.41,1.6,;-1.95,1.6,;-2.86,2.84,;-4.32,2.37,;-5.66,3.14,;-6.99,2.37,;-6.99,.83,;-5.66,.06,;-4.32,.83,;-2.86,.35,;-2.46,-1.14,;-3.55,-2.22,;-3.15,-3.71,;-1.66,-4.11,;-1.27,-5.6,;-.57,-3.02,;-.97,-1.53,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [695-1022,T790M,C797S,L858R] (Homo sapiens (Human))	BDBM525490 (US11174245, # I-143) Show SMILES Cc1cc(cc(n1)-c1cnn(C)c1)C(=O)\N=c1/[nH]c2ccccc2n1[C@@H]1CC[C@H](O)CC1 |r,wU:25.28,28.32,(4.98,5.6,;4.21,4.26,;2.67,4.26,;1.9,2.93,;2.67,1.6,;4.21,1.6,;4.98,2.93,;4.98,.26,;6.52,.26,;6.99,-1.2,;5.75,-2.11,;5.75,-3.65,;4.5,-1.2,;.36,2.93,;-.41,4.26,;-.41,1.6,;-1.95,1.6,;-2.86,2.84,;-4.32,2.37,;-5.66,3.14,;-6.99,2.37,;-6.99,.83,;-5.66,.06,;-4.32,.83,;-2.86,.35,;-2.46,-1.14,;-3.55,-2.22,;-3.15,-3.71,;-1.66,-4.11,;-1.27,-5.6,;-.57,-3.02,;-.97,-1.53,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [695-1022] (Homo sapiens (Human))	BDBM525490 (US11174245, # I-143) Show SMILES Cc1cc(cc(n1)-c1cnn(C)c1)C(=O)\N=c1/[nH]c2ccccc2n1[C@@H]1CC[C@H](O)CC1 |r,wU:25.28,28.32,(4.98,5.6,;4.21,4.26,;2.67,4.26,;1.9,2.93,;2.67,1.6,;4.21,1.6,;4.98,2.93,;4.98,.26,;6.52,.26,;6.99,-1.2,;5.75,-2.11,;5.75,-3.65,;4.5,-1.2,;.36,2.93,;-.41,4.26,;-.41,1.6,;-1.95,1.6,;-2.86,2.84,;-4.32,2.37,;-5.66,3.14,;-6.99,2.37,;-6.99,.83,;-5.66,.06,;-4.32,.83,;-2.86,.35,;-2.46,-1.14,;-3.55,-2.22,;-3.15,-3.71,;-1.66,-4.11,;-1.27,-5.6,;-.57,-3.02,;-.97,-1.53,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [695-1022] (Homo sapiens (Human))	BDBM525490 (US11174245, # I-143) Show SMILES Cc1cc(cc(n1)-c1cnn(C)c1)C(=O)\N=c1/[nH]c2ccccc2n1[C@@H]1CC[C@H](O)CC1 |r,wU:25.28,28.32,(4.98,5.6,;4.21,4.26,;2.67,4.26,;1.9,2.93,;2.67,1.6,;4.21,1.6,;4.98,2.93,;4.98,.26,;6.52,.26,;6.99,-1.2,;5.75,-2.11,;5.75,-3.65,;4.5,-1.2,;.36,2.93,;-.41,4.26,;-.41,1.6,;-1.95,1.6,;-2.86,2.84,;-4.32,2.37,;-5.66,3.14,;-6.99,2.37,;-6.99,.83,;-5.66,.06,;-4.32,.83,;-2.86,.35,;-2.46,-1.14,;-3.55,-2.22,;-3.15,-3.71,;-1.66,-4.11,;-1.27,-5.6,;-.57,-3.02,;-.97,-1.53,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [695-1022,T790M,C797S,L858R] (Homo sapiens (Human))	BDBM525490 (US11174245, # I-143) Show SMILES Cc1cc(cc(n1)-c1cnn(C)c1)C(=O)\N=c1/[nH]c2ccccc2n1[C@@H]1CC[C@H](O)CC1 |r,wU:25.28,28.32,(4.98,5.6,;4.21,4.26,;2.67,4.26,;1.9,2.93,;2.67,1.6,;4.21,1.6,;4.98,2.93,;4.98,.26,;6.52,.26,;6.99,-1.2,;5.75,-2.11,;5.75,-3.65,;4.5,-1.2,;.36,2.93,;-.41,4.26,;-.41,1.6,;-1.95,1.6,;-2.86,2.84,;-4.32,2.37,;-5.66,3.14,;-6.99,2.37,;-6.99,.83,;-5.66,.06,;-4.32,.83,;-2.86,.35,;-2.46,-1.14,;-3.55,-2.22,;-3.15,-3.71,;-1.66,-4.11,;-1.27,-5.6,;-.57,-3.02,;-.97,-1.53,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair