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SMILES: Cn1cc(cn1)-c1cc(cc(n1)C#N)C(=O)\N=c1/[nH]c2cc(CN3CCOCC3)ccc2n1[C@@H]1CC[C@H](O)CC1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 525492   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [695-1022] (Homo sapiens (Human))	BDBM525492 (US11174245, # I-145) Show SMILES Cn1cc(cn1)-c1cc(cc(n1)C#N)C(=O)\N=c1/[nH]c2cc(CN3CCOCC3)ccc2n1[C@@H]1CC[C@H](O)CC1 |r,wU:33.37,36.41,(8.41,-4.31,;8.41,-2.77,;7.17,-1.87,;7.64,-.4,;9.18,-.4,;9.66,-1.87,;6.87,.93,;5.33,.93,;4.56,2.26,;5.33,3.6,;6.87,3.6,;7.64,2.26,;7.64,4.93,;8.41,6.27,;3.02,2.26,;2.25,3.6,;2.25,.93,;.71,.93,;-.19,2.18,;-1.66,1.7,;-2.99,2.47,;-4.32,1.7,;-5.66,2.47,;-6.99,1.7,;-8.33,2.47,;-9.66,1.7,;-9.66,.16,;-8.33,-.61,;-6.99,.16,;-4.32,.16,;-2.99,-.61,;-1.66,.16,;-.19,-.32,;.21,-1.8,;-.88,-2.89,;-.48,-4.38,;1,-4.78,;1.4,-6.27,;2.09,-3.69,;1.69,-2.2,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	397	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [695-1022,T790M,C797S,L858R] (Homo sapiens (Human))	BDBM525492 (US11174245, # I-145) Show SMILES Cn1cc(cn1)-c1cc(cc(n1)C#N)C(=O)\N=c1/[nH]c2cc(CN3CCOCC3)ccc2n1[C@@H]1CC[C@H](O)CC1 |r,wU:33.37,36.41,(8.41,-4.31,;8.41,-2.77,;7.17,-1.87,;7.64,-.4,;9.18,-.4,;9.66,-1.87,;6.87,.93,;5.33,.93,;4.56,2.26,;5.33,3.6,;6.87,3.6,;7.64,2.26,;7.64,4.93,;8.41,6.27,;3.02,2.26,;2.25,3.6,;2.25,.93,;.71,.93,;-.19,2.18,;-1.66,1.7,;-2.99,2.47,;-4.32,1.7,;-5.66,2.47,;-6.99,1.7,;-8.33,2.47,;-9.66,1.7,;-9.66,.16,;-8.33,-.61,;-6.99,.16,;-4.32,.16,;-2.99,-.61,;-1.66,.16,;-.19,-.32,;.21,-1.8,;-.88,-2.89,;-.48,-4.38,;1,-4.78,;1.4,-6.27,;2.09,-3.69,;1.69,-2.2,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 μL of EGFR enzyme form in assay buffer (50 mM HEPES pH 7.3, 10 mM MgCl2, 1 mM EGTA, 0.01% Tween 20, 2 mM DTT) are dispensed into columns 1-23,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56F9
					More data for this Ligand-Target Pair