null

SMILES: Cc1ccc(Nc2nc(cc3ncn(C4CC4)c23)-c2ccc3c(c2)N([C@H]2C[C@H](C2)N2CCC[C@@H](F)C2)C(=O)C3(C)C)cc1C(N)=O

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 529602   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human))	BDBM529602 (US11203591, Example 17) Show SMILES Cc1ccc(Nc2nc(cc3ncn(C4CC4)c23)-c2ccc3c(c2)N([C@H]2C[C@H](C2)N2CCC[C@@H](F)C2)C(=O)C3(C)C)cc1C(N)=O |r,wU:25.28,27.33,33.38,(-1.71,-4.45,;-.37,-3.68,;-.37,-2.14,;.96,-1.37,;2.29,-2.14,;3.63,-1.37,;3.63,.17,;2.29,.94,;2.29,2.48,;3.63,3.25,;4.96,2.48,;6.43,2.96,;7.33,1.71,;6.43,.47,;6.83,-1.02,;6.43,-2.51,;7.91,-2.11,;4.96,.94,;.96,3.25,;.96,4.79,;-.37,5.56,;-1.71,4.79,;-1.71,3.25,;-.37,2.48,;-3.17,2.78,;-3.57,1.29,;-2.8,-.04,;-4.13,-.81,;-4.9,.52,;-4.53,-2.3,;-3.42,-3.4,;-3.82,-4.91,;-5.33,-5.31,;-6.43,-4.2,;-7.91,-4.6,;-6.02,-2.7,;-4.08,4.02,;-5.62,4.02,;-3.17,5.27,;-4.26,6.36,;-2.77,6.76,;2.29,-3.68,;.96,-4.45,;.96,-5.99,;2.29,-6.76,;-.37,-6.76,)| Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...				Citation and Details BindingDB Entry DOI: 10.7270/Q2833W6Q
					More data for this Ligand-Target Pair