null
SMILES: C[C@@H]1Cc2cnc(NCc3ccn(C)n3)nc2CN1C(=O)[C@@H]1CCN(C)C[C@H]1c1cccc(C)c1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530357![]() (WO2022064009, Compound 136 | WO2022064009, Compoun...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Compounds with potencies approaching the limit o... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530357![]() (WO2022064009, Compound 136 | WO2022064009, Compoun...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 1.38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530357![]() (WO2022064009, Compound 136 | WO2022064009, Compoun...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | <9.77 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Compounds with potencies approaching the limit o... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530357![]() (WO2022064009, Compound 136 | WO2022064009, Compoun...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair |