null

SMILES: Cc1cc(cc(O)c1-c1ccc(N[C@H]2C[C@@](C)(O)C2)nn1)C(F)(F)F

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 531221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tumor necrosis factor (Homo sapiens (Human))	BDBM531221 (2-(6-(((cis)-3-Hydroxy-3-methylcyclobutyl)amino)py...) Show SMILES Cc1cc(cc(O)c1-c1ccc(N[C@H]2C[C@@](C)(O)C2)nn1)C(F)(F)F |r,wU:15.16,wD:13.13,15.17,(-1.69,2.69,;-3.02,1.93,;-4.35,2.69,;-5.69,1.93,;-5.69,.38,;-4.35,-.38,;-4.35,-1.93,;-3.02,.38,;-1.69,-.38,;-.35,.38,;.98,-.38,;.98,-1.93,;2.31,-2.69,;3.65,-1.93,;5.14,-2.32,;5.53,-.84,;7.02,-1.23,;6.3,.5,;4.05,-.44,;-.35,-2.69,;-1.69,-1.93,;-7.02,2.69,;-7.02,4.23,;-8.35,1.92,;-8.36,3.46,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Monocytic THP-1 cells were maintained according to providers' instructions in RPMI media as described above. Undifferentiated cells were plated a...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5
					More data for this Ligand-Target Pair
Interleukin-1 beta (Homo sapiens (Human))	BDBM531221 (2-(6-(((cis)-3-Hydroxy-3-methylcyclobutyl)amino)py...) Show SMILES Cc1cc(cc(O)c1-c1ccc(N[C@H]2C[C@@](C)(O)C2)nn1)C(F)(F)F |r,wU:15.16,wD:13.13,15.17,(-1.69,2.69,;-3.02,1.93,;-4.35,2.69,;-5.69,1.93,;-5.69,.38,;-4.35,-.38,;-4.35,-1.93,;-3.02,.38,;-1.69,-.38,;-.35,.38,;.98,-.38,;.98,-1.93,;2.31,-2.69,;3.65,-1.93,;5.14,-2.32,;5.53,-.84,;7.02,-1.23,;6.3,.5,;4.05,-.44,;-.35,-2.69,;-1.69,-1.93,;-7.02,2.69,;-7.02,4.23,;-8.35,1.92,;-8.36,3.46,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JD50Z5
					More data for this Ligand-Target Pair