null
SMILES: CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)C(=O)NO)nc2n(C2CCCC2)c1=O
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM533757![]() (Preparation of 6-((6-acetyl-8-cyclopentyl-5-methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 (Homo sapiens (Human)) | BDBM533757![]() (Preparation of 6-((6-acetyl-8-cyclopentyl-5-methyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM533757![]() (Preparation of 6-((6-acetyl-8-cyclopentyl-5-methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The inhibitory effect of compounds on HDAC-1, HDAC-2 and HDAC-6 function was determined in vitro using an optimized homogenous assay performed in 384... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM533757![]() (Preparation of 6-((6-acetyl-8-cyclopentyl-5-methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The inhibitory effect of compounds on HDAC-1, HDAC-2 and HDAC-6 function was determined in vitro using an optimized homogenous assay performed in 384... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Homo sapiens (Human)) | BDBM533757![]() (Preparation of 6-((6-acetyl-8-cyclopentyl-5-methyl...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor... | Citation and Details BindingDB Entry DOI: 10.7270/Q27S7RZ1 | |||||||||||
More data for this Ligand-Target Pair |