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SMILES: CC(=O)N1CCCCC1C(=O)N1C[C@H](O)CC1C1=NC(=O)[C@@](C)(N1)c1ccc(cc1)-c1scnc1C
InChI Key:
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213] (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213] (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.50E+5 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213] (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213] (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213] (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213] (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.50E+5 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213] (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213] (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.50E+5 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM536187 ((5S)-2-((4R)-1-(1-acetylpiperidine-2-carbonyl)-4-h...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
