null
SMILES: CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C1=NOC(N1)(c1ccccc1)c1ccccc1)c1cc(C)no1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213] (Homo sapiens (Human)) | BDBM536245 ((R)-1-((2S,4R)-2-(5,5-diphenyl-4,5-dihydro-1,2,4-o...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.57E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
von Hippel-Lindau disease tumor suppressor (Homo sapiens (Human)) | BDBM536245 ((R)-1-((2S,4R)-2-(5,5-diphenyl-4,5-dihydro-1,2,4-o...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213] (Homo sapiens (Human)) | BDBM536245 ((R)-1-((2S,4R)-2-(5,5-diphenyl-4,5-dihydro-1,2,4-o...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KW5K7X | |||||||||||
More data for this Ligand-Target Pair |