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SMILES: CC(C)[C@H](C(=O)N1C[C@H](O)C[C@@H]1C1=NC(=O)C(C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(OCCCCCNC(=O)c2cc3N(Cc4c[nH]c5c4c(cn(C)c5=O)-c3cc2CS(C)(=O)=O)c2ncc(F)cc2F)no1

InChI Key:

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 536277   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))
BDBM536277
PNG
(US11242344, Example 1001.2 | US11242344, Example 1...)
Show SMILES CC(C)[C@H](C(=O)N1C[C@H](O)C[C@@H]1C1=NC(=O)C(C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(OCCCCCNC(=O)c2cc3N(Cc4c[nH]c5c4c(cn(C)c5=O)-c3cc2CS(C)(=O)=O)c2ncc(F)cc2F)no1 |r,t:13|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair
Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]


(Homo sapiens (Human))
BDBM536277
PNG
(US11242344, Example 1001.2 | US11242344, Example 1...)
Show SMILES CC(C)[C@H](C(=O)N1C[C@H](O)C[C@@H]1C1=NC(=O)C(C)(N1)c1ccc(cc1)-c1scnc1C)c1cc(OCCCCCNC(=O)c2cc3N(Cc4c[nH]c5c4c(cn(C)c5=O)-c3cc2CS(C)(=O)=O)c2ncc(F)cc2F)no1 |r,t:13|
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 795n/an/an/an/an/an/a


TBA

Assay Description
The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2KW5K7X
More data for this
Ligand-Target Pair