null
SMILES: CN1CCc2ccc(Nc3ncc4c(N)c(F)c(c(Cl)c4n3)-c3cnc4OCCNc4c3C)cc2C1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM548834 (WO2022098806, Compound 2-180 | WO2022098806, Compo...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022098806 | n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KH0RJB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM548834 (WO2022098806, Compound 2-180 | WO2022098806, Compo...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022098806 | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &... | Citation and Details BindingDB Entry DOI: 10.7270/Q2KH0RJB | |||||||||||
More data for this Ligand-Target Pair |