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SMILES: CN(C)[C@@H]1CCN(C1)C(=O)c1cc2c(Nc3cc(C)c4C(=O)NC5(CCC5)n4c3=O)ncnc2s1

InChI Key:

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 550662   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))		BDBM550662
PNG
(6′-[(6-{[(3R)-3-(Dimethylamino)pyrrolidin-1-...)
Show SMILES CN(C)[C@@H]1CCN(C1)C(=O)c1cc2c(Nc3cc(C)c4C(=O)NC5(CCC5)n4c3=O)ncnc2s1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a


TBA

Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VT1W9T
More data for this
Ligand-Target Pair