null
SMILES: CCc1c-2c(CN(C)S(=O)(=O)CCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43] (Homo sapiens (Human)) | BDBM562363![]() ((+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MCL-1/Noxa BH3 Peptide (MCL-1 Assay): From there, 50 nl were transferred in a dark test plate (Greiner Bio-One, Frickenhausen, Germany). The assay wa... | Citation and Details BindingDB Entry DOI: 10.7270/Q2930XCJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1/Bcl2-associated agonist of cell death [103-127,M117N] (Homo sapiens (Human)) | BDBM562363![]() ((+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-y...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description BCL-XL/Bad BH3 Peptide (BCL-XL Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-XL solution (usually for a... | Citation and Details BindingDB Entry DOI: 10.7270/Q2930XCJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apoptosis regulator Bcl-2/Bcl2-associated agonist of cell death [103-127,M117N] (Homo sapiens (Human)) | BDBM562363![]() ((+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-y...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2930XCJ | |||||||||||
More data for this Ligand-Target Pair |