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SMILES: CNC(=O)c1cc2[nH]c(nc2cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccc1

InChI Key:

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 564307   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM564307
PNG
(Roche-Dataset for PDE10A, Compound 621)
Show SMILES CNC(=O)c1cc2[nH]c(nc2cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccc1
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PC cid
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PubMed
n/an/a 0.0900n/an/an/an/an/an/a


TBA

Assay Description
Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...

Citation and Details

Article DOI: 10.1007/s10822-022-00478-x
BindingDB Entry DOI: 10.7270/Q29W0JQD
More data for this
Ligand-Target Pair