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SMILES: CC1(O)CCCN(C1)C1C=C[N](=N1)c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 570426   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM570426 (US11434240, Compound I-62) Show SMILES CC1(O)CCCN(C1)C1C=C[N](=N1)c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |c:10,12| Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM570426 (US11434240, Compound I-62) Show SMILES CC1(O)CCCN(C1)C1C=C[N](=N1)c1cc(nc2CNC(=O)c12)-c1c(F)cccc1C#N |c:10,12| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Peptide substrate, [KKSRGDYMTMQIG], (20 μM) is prepared in reaction buffer (20 mM Hepes pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QV3QRF
					More data for this Ligand-Target Pair