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SMILES: COC1CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2ccccc12

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 574839   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM574839
PNG
(US11459315, Example 4 (isomer 2))
Show SMILES COC1CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2ccccc12 |r,wU:9.13,wD:12.14,(10.41,-4.86,;8.88,-5.38,;7.95,-4.04,;6.45,-3.78,;6.68,-2.36,;8.21,-2.54,;5.71,-1.01,;6.34,.4,;5.45,1.64,;3.92,1.45,;3.32,.03,;4.21,-1.16,;2.95,2.72,;3.62,4.1,;1.45,2.49,;.37,3.69,;.74,5.26,;-.97,3.13,;-2.39,3.84,;-2.39,5.38,;-3.7,3.02,;-5.08,3.84,;-6.38,3.09,;-6.42,1.52,;-5.07,.7,;-5.07,-.84,;-7.65,.78,;-9.1,1.52,;-10.41,.78,;-9.11,3.02,;-7.8,3.84,;-7.8,5.38,;-.86,1.49,;-1.83,.44,;-1.38,-1.09,;.15,-1.35,;1.12,-.3,;.63,1.23,)|
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a


TBA

Assay Description
Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76H4
More data for this
Ligand-Target Pair