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SMILES: CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(F)C2)c2ncccc12

InChI Key:

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 574922   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM574922
PNG
(1-((R)-1-(4-(3-fluoroazetidin-1-yl)cyclohexyl)ethy...)
Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(F)C2)c2ncccc12 |wU:18.19,(1.96,-3.26,;3.45,-3.66,;3.85,-5.15,;5.34,-5.54,;5.74,-7.03,;7.22,-7.43,;4.65,-8.12,;3.16,-7.72,;2.07,-8.81,;2.76,-6.24,;1.27,-5.84,;.87,-4.35,;-.61,-3.95,;-1.7,-5.04,;-1.09,-2.49,;-.18,-1.24,;1.36,-1.24,;-1.09,.01,;-.61,1.47,;.89,1.79,;-1.64,2.62,;-3.15,2.3,;-4.18,3.44,;-3.7,4.9,;-2.2,5.22,;-1.17,4.08,;-4.74,6.05,;-6.27,6.13,;-6.19,7.67,;-7.22,8.81,;-4.65,7.59,;-2.55,-.47,;-3.89,.3,;-5.22,-.47,;-5.22,-2.01,;-3.89,-2.78,;-2.55,-2.01,)|
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a


TBA

Assay Description
Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76H4
More data for this
Ligand-Target Pair