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SMILES: COCCOC1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2ccccc12

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 574924   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM574924
PNG
(1-((R)-1-(4-(2-methoxyethoxy)cyclohex-yl)ethyl)-2-...)
Show SMILES COCCOC1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2ccccc12 |wU:11.12,8.7,(7.86,-4.14,;6.37,-3.74,;5.28,-4.83,;3.79,-4.43,;2.7,-5.52,;1.22,-5.12,;.82,-3.63,;-.67,-3.23,;-1.76,-4.32,;-1.36,-5.81,;.13,-6.21,;-3.25,-3.93,;-4.34,-5.01,;-3.72,-2.46,;-2.82,-1.21,;-1.28,-1.21,;-3.72,.03,;-3.25,1.5,;-4.28,2.64,;-1.74,1.82,;-1.27,3.28,;.24,3.6,;.72,5.07,;-.31,6.21,;-1.82,5.89,;2.22,5.39,;3.25,4.24,;4.76,4.56,;2.78,2.78,;1.27,2.46,;.8,.99,;-5.19,-.44,;-6.52,.33,;-7.86,-.44,;-7.86,-1.98,;-6.52,-2.75,;-5.19,-1.98,)|
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a


TBA

Assay Description
Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76H4
More data for this
Ligand-Target Pair