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SMILES: CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CCCC2=O)c2ccccc12

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 574931   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM574931
PNG
(2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dih...)
Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CCCC2=O)c2ccccc12 |wU:18.19,(-.49,6.26,;1.02,6.58,;2.05,5.44,;3.56,5.76,;4.59,4.61,;6.09,4.94,;4.11,3.15,;2.6,2.83,;2.13,1.37,;1.57,3.97,;.07,3.65,;-.41,2.19,;-1.92,1.87,;-2.95,3.01,;-2.39,.4,;-1.49,-.84,;.05,-.84,;-2.39,-2.09,;-1.92,-3.55,;-3,-4.64,;-.43,-3.95,;.66,-2.86,;2.15,-3.26,;2.55,-4.75,;1.46,-5.84,;-.03,-5.44,;4.03,-5.15,;4.59,-6.58,;6.12,-6.5,;6.52,-5.02,;5.23,-4.18,;5.23,-2.64,;-3.86,-1.61,;-5.19,-2.38,;-6.52,-1.61,;-6.52,-.07,;-5.19,.7,;-3.86,-.07,)|
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a


TBA

Assay Description
Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76H4
More data for this
Ligand-Target Pair