null
SMILES: CCOc1cc(cc(n1)N1Cc2c(cc(CN3CCC[C@H](C)C3)nc2C2CC2)C1=O)C1(Cc2nncn2C)COC1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427] (Homo sapiens (Human)) | BDBM575677 (US11464802, Compound 40) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2V98CBJ | |||||||||||
More data for this Ligand-Target Pair |