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SMILES: CCNc1cc(cc(n1)N1Cc2c(cc(CN3CCC[C@H](C)C3)cc2C(F)(F)F)C1=O)C1(Cc2nncn2C)COC1

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575681   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))		BDBM575681
PNG
(US11464802, Compound 44)
Show SMILES CCNc1cc(cc(n1)N1Cc2c(cc(CN3CCC[C@H](C)C3)cc2C(F)(F)F)C1=O)C1(Cc2nncn2C)COC1 |r|
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair